Purposes Several studies have reported that elevated red cell distribution width (RDW) is related to poor prognosis in several cancers; however, the prognostic significance of perioperative RDW in rectal cancer patients which received neoadjuvant chemoradiation therapy (NACRT) is unclear. Methods A total of 120 rectal cancer patients who received NACRT followed surgery were retrospectively reviewed from Affiliated Cancer Hospital of Zhengzhou University between 2013 to 2015. Data for peripheral blood tests prior to the initiation of NACRT，before surgery and first chemotherapy after surgery were collected，respectively. The optimal cutoff values of RDW was determined by ROC analysis, respectively. The relationship between RDW and the prognosis of patients was evaluated by, respectively. Results The post-operative RDWHigh (≥15.55) patients had significantly worse five-year overall survival (OS, P=0.001) and disease-free survival (DFS, P=0.001) than the post-operative RDWLow (<15.55) patients, respectively. Whereas high pre-operative RDW (≥16.45) was the only marker correlated with worse DFS (P=0.005) than the pre-operative RDWLow (<16.45)patients, no relationship was found between pre-RDW and prognosis(OS, P=0.069; DFS, P=0.133). Multivariate analysis showed post-operative RDW had better predictive value than pre-RDW and pre-operative RDW. Conclusion Post-operative RDW might be a useful prognostic indicator in rectal cancer patients received neoadjuvant chemoradiation.

中文翻译：

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直肠癌新辅助放化疗患者术后红细胞分布宽度的预后价值。

目的多项研究报道，红细胞分布宽度（RDW）升高与几种癌症的预后不良有关。然而，尚不清楚围手术期RDW在接受新辅助化学放疗（NACRT）的直肠癌患者中的预后意义。方法对2013年至2015年在郑州大学附属肿瘤医院收治的120例接受NACRT手术治疗的直肠癌患者进行回顾性分析。收集NACRT启动前，手术前及术后首次化疗的外周血检查数据，分别。通过ROC分析分别确定RDW的最佳截止值。通过分别评估RDW与患者预后之间的关系。结果术后RDWHigh（≥15。55）患者的五年总体生存率（OS，P = 0.001）和无病生存期（DFS，P = 0.001）分别比术后RDWLow（<15.55）患者差。与术前RDWLow（<16.45）的患者相比，术前RDW高（≥16.45）是与DFS更差（P = 0.005）相关的唯一标志，但RDW术前与预后之间无相关性（OS，P = 0.069； DFS，P = 0.133）。多元分析表明，术后RDW的预测价值优于RDW术前和RDW。结论RDW可能是直肠癌患者接受新辅助化学放疗的预后指标。45）是唯一与DFS（P = 0.005）较术前RDWLow（<16.45）患者差的相关标志物，RDW前与预后之间无相关性（OS，P = 0.069; DFS，P = 0.133） 。多元分析表明，术后RDW的预测价值优于RDW术前和RDW。结论RDW可能是直肠癌患者接受新辅助化学放疗的预后指标。45）是唯一与DFS（P = 0.005）较术前RDWLow（<16.45）患者差的相关标志物，RDW前与预后之间无相关性（OS，P = 0.069; DFS，P = 0.133） 。多元分析表明，术后RDW的预测价值优于RDW术前和RDW。结论RDW可能是直肠癌患者接受新辅助化学放疗的预后指标。