Garcinia lanceifolia Roxb. has been used by many ethnic communities of Northeast India to mitigate various disorders like dyspepsia, ulcers, diabetes, etc. However, a robust scientific study on its antidiabetic and antiulcer potential is unavailable till date. The aim of this present study is to scientifically validate if the antidiabetic and antiulcer effects reported by the ethnic tribes of Assam has any scientific value or not. The effects were tested in adult Wistar albino rats using approved animal models for preclinical testing of pharmacological activities. The hydroalcoholic extract of the bark of Garcinia lanceifolia Roxb. was prepared and its LD50 was calculated. The LD50 was determined to be greater than 5000 mg/kg body weight. The extract at doses of 250 mg/kg body weight and 500 mg/kg body weight was found to exhibit a very potent dose-dependent antidiabetic activity. The results were backed by a battery of test including analysis of serum levels of blood glucose, lipid profiles, in vivo antioxidant enzymes, and histopathological studies. Evidence of dose-dependent antiulcer activity of the extract was backed by robust scientific data. It was found that HAEGL induced a significant dose-dependent increase in the ulcer index in both alcohol-induced and acetic acid-induced ulcer models, which was evident from the macroscopic observation of the inner lining of the gastric mucosa and the histological evaluation of the extracted stomach. The results suggested that the bark of Garcinia lanceifolia (Roxb.) has significant antidiabetic and antiulcer potential. Further studies with respect to the development herbal dosage forms and its safety evaluation are required.

中文翻译：

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藤黄的抗糖尿病和抗溃疡潜力。吠

藤黄。印度东北的许多种族已经使用它来减轻消化不良，溃疡，糖尿病等各种疾病。但是，迄今为止，尚无关于其抗糖尿病和抗溃疡潜力的强有力的科学研究。本研究的目的是科学地验证阿萨姆邦部落报告的抗糖尿病和抗溃疡作用是否具有科学价值。使用批准的动物模型对药理活性进行临床前测试，在成年Wistar白化病大鼠中测试了这种作用。藤黄果皮的水醇提取物。准备并计算其LD50。经测定，LD50大于5000 mg / kg体重。发现以250mg / kg体重和500mg / kg体重的剂量的提取物表现出非常有效的剂量依赖性抗糖尿病活性。该结果得到了一系列测试的支持，其中包括对血清血糖水平，脂质分布，体内抗氧化酶的分析以及组织病理学研究。可靠的科学数据支持了提取物的剂量依赖性抗溃疡活性证据。已发现，HAEGL在酒精诱导和乙酸诱导的溃疡模型中均引起溃疡指数的显着剂量依赖性增加，这从肉眼观察到的胃粘膜内层的内衬和组织学评价可见。提取胃。结果表明藤黄（Garcinia lanceifolia）（Roxb。）的树皮具有显着的抗糖尿病和抗溃疡的潜力。