The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. The subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pubertal groups (n = 47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance was independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone. This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.

中文翻译：

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肠道微生物群：青春期状态的影响

尚未报道不同青春期阶段肠道微生物群的构成。这项横断面研究分析了不同青春期阶段肠道微生物群的生物多样性。受试者（5-15 岁）分为非青春期组（n = 42，男性%：66.7%）或青春期组（n = 47，男性%：44.68）；在两组中，厚壁菌门、拟杆菌门和变形菌门是优势门。在不同的青春期阶段，α-多样性和β-多样性没有差异。非青春期受试者具有梭菌目、梭菌科、粪杆菌属的成员，其比青春期受试者显着更普遍。此外，青春期受试者具有比非青春期受试者显着更普遍的 Betaproteobacteria 类成员，即伯克霍尔德氏菌目。它们的相对丰度与 BMI-Z 无关。在青春期受试者中，Adlercreutzia、Ruminococcus、Dorea、Clostridium 和 Parabacteroides 属的丰度与睾酮水平有关。这是关于青春期不同阶段肠道微生物群多样性的第一份报告。不同种类的肠道微生物群随着青春期阶段逐渐发生变化。不同青春期状态下肠道菌群的差异可能与雄激素水平有关。