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Gold-Catalyzed Synthesis of Small Rings
Chemical Reviews ( IF 62.1 ) Pub Date : 2020-11-02 , DOI: 10.1021/acs.chemrev.0c00697
Mauro Mato 1, 2 , Allegra Franchino 1, 2 , Cristina Garcı A-Morales 1, 2 , Antonio M Echavarren 1, 2
Affiliation  

Three- and four-membered rings, widespread motifs in nature and medicinal chemistry, have fascinated chemists ever since their discovery. However, due to energetic considerations, small rings are often difficult to assemble. In this regard, homogeneous gold catalysis has emerged as a powerful tool to construct these highly strained carbocycles. This review aims to provide a comprehensive summary of all the major advances and discoveries made in the gold-catalyzed synthesis of cyclopropanes, cyclopropenes, cyclobutanes, cyclobutenes, and their corresponding heterocyclic or heterosubstituted analogs.

中文翻译:

金催化合成小环

三元环和四元环是自然界和药物化学中广泛存在的基序,自发现以来一直让化学家着迷。然而,出于能量考虑,小环通常难以组装。在这方面,均相金催化已成为构建这些高应变碳环的有力工具。本综述旨在全面总结金催化合成环丙烷、环丙烯、环丁烷、环丁烯及其相应杂环或杂取代类似物的所有主要进展和发现。
更新日期:2020-11-02
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