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Modulation of pro-inflammatory and pro-resolution mediators by γ-linolenic acid: an important element in radioprotection against ionizing radiation
Archives of Medical Science ( IF 3.8 ) Pub Date : 2020-01-29 , DOI: 10.5114/aoms.2020.92469
Rangachar Poorani 1, 2 , Anant N Bhatt 1 , Undurti N Das 2, 3
Affiliation  

The current study explored the radio-protective property of g-linolenic acid (GLA) in C57BL/6J mice against low linear energy transfer ionizing radiation (IR; X-rays) and its modulatory effect on the production of lipid mediators such as prostaglandin E2 (PGE2), leukotriene E4 and lipoxin A4 (LXA4) in mice plasma. The effect of GLA pre-treatment on radiation induced inflammation was assessed by estimating plasma levels of high mobility group box 1 protein (HMGB1), TMOP/NO and various anti-oxidant enzymes. g-linolenic acid pre-treated mice exposed to lethal IR dose (7.5 Gy) showed a decrease in plasma levels of HMGB1, PGE2 and LXA4 and a fall in TMOP/NO ratio and improvement in anti-oxidant enzymes: catalase, glutathione transferase and glutathione peroxidase compared to IR mice, suggesting that GLA suppresses IR-induced inflammation and restores the pro- vs. anti-oxidant ratio to near normal, which could explain its radioprotective action.

中文翻译:

γ-亚麻酸对促炎和促消退介质的调节:电离辐射辐射防护的重要元素

目前的研究探讨了 g-亚麻酸 (GLA) 在 C57BL/6J 小鼠中对低线性能量转移电离辐射 (IR; X 射线) 的辐射防护特性及其对脂质介质如前列腺素 E2 产生的调节作用(PGE2)、白三烯 E4 和脂氧素 A4 (LXA4) 在小鼠血浆中。GLA 预处理对辐射诱导的炎症的影响通过估计血浆中高迁移率组框 1 蛋白 (HMGB1)、TMOP/NO 和各种抗氧化酶的水平来评估。暴露于致死 IR 剂量 (7.5 Gy) 的 g-亚麻酸预处理小鼠显示血浆 HMGB1、PGE2 和 LXA4 水平降低,TMOP/NO 比率下降,抗氧化酶:过氧化氢酶、谷胱甘肽转移酶和与 IR 小鼠相比,谷胱甘肽过氧化物酶,
更新日期:2020-01-29
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