Natural organisms make a wide variety of exquisitely complex, nano-, micro-, and macroscale structured materials in an energy-efficient and highly reproducible manner. During these processes, the information-carrying biomolecules (e.g., proteins, peptides, and carbohydrates) enable (1) hierarchical organization to assemble scaffold materials and execute high-level functions and (2) exquisite control over inorganic materials synthesis, generating biominerals whose properties are optimized for their functions. Inspired by nature, significant efforts have been devoted to developing functional materials that can rival those natural molecules by mimicking in vivo functions using engineered proteins, peptides, DNAs, sequence-defined synthetic molecules (e.g., peptoids), and other biomimetic polymers. Among them, peptoids, a new type of synthetic mimetics of peptides and proteins, have received particular attention because they combine the merits of both synthetic polymers (e.g., high chemical stability and efficient synthesis) and biomolecules (e.g., sequence programmability and biocompatibility). The lack of both chirality and hydrogen bonds in their backbone results in a highly designable peptoid-based system with reduced structural complexity and side chain-chemistry-dominated properties.

中文翻译：

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编程两亲拟肽低聚物，用于层次组装和无机结晶

天然生物以高能效和高可重复性的方式制造各种各样的复杂，纳米，微米和宏观结构的材料。在这些过程中，携带信息的生物分子（例如蛋白质，肽和碳水化合物）使得（1）层级组织能够组装支架材料并执行高级功能；以及（2）对无机材料合成的精确控制，从而产生其特性的生物矿物针对其功能进行了优化。受自然界的启发，人们投入了巨大的努力来开发功能材料，这些材料可以通过使用工程蛋白，肽，DNA，序列定义的合成分子（例如类肽）和其他仿生聚合物模仿体内功能来与天然分子竞争。其中，类肽，一种新型的肽和蛋白质合成模拟物受到了特别的关注，因为它们结合了合成聚合物（例如，高化学稳定性和高效合成）和生物分子（例如，序列可编程性和生物相容性）的优点。它们的主链中缺乏手性和氢键，导致了高度可设计的类肽基体系，具有降低的结构复杂性和侧链化学主导的特性。