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Impact of Intraoperative Cell Salvage on Concentrations of Antibiotics Used for Surgical Prophylaxis
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2020-11-17 , DOI: 10.1128/aac.01725-20
Maxwell J Lasko 1 , Allison M Conelius 2 , Oscar K Serrano 3, 4 , David P Nicolau 1, 5 , Joseph L Kuti 6
Affiliation  

Intraoperative cell salvage (IOCS) is used to administer autologous blood lost during surgery. We studied antibiotic disposition through an ex vivo IOCS system for vancomycin, piperacillin, ampicillin, and cefazolin. Only 2% ± 1% of antibiotic inoculated in whole blood was recovered in the IOCS reinfusion bag, whereas 97% ± 17% was found in the waste. These observations were confirmed for ampicillin in two patients undergoing liver transplantation. Studies measuring the impact of IOCS on perioperative antibiotic concentrations are warranted.

中文翻译:

术中抢救细胞对手术预防用抗生素浓度的影响

术中细胞抢救(IOCS)用于管理手术过程中丢失的自体血液。我们通过离体IOCS系统研究了万古霉素,哌拉西林,氨苄青霉素和头孢唑林的抗生素处置情况。IOCS再输注袋中仅回收了全血中接种的抗生素的2%±1%,而在废物中发现了97%±17%。这些观察结果在两名接受肝移植的患者中得到了氨苄西林的证实。有必要进行测量IOCS对围手术期抗生素浓度影响的研究。
更新日期:2020-11-17
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