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Enantioselective Synthesis of Difluoroalkylated Isoindolinones via Chiral Spirocyclic Phosphoric Acid-Catalyzed Mannich-type Reaction
Synlett ( IF 2 ) Pub Date : 2020-09-29 , DOI: 10.1055/a-1274-2959
Xufeng Lin 1 , Lei Wang , Jialing Zhong
Affiliation  

An enantioselective Mannich-type reaction of in situ generated cyclic ketimines with difluoroenoxysilanes catalyzed by chiral spirocyclic phosphoric acid has been developed. This methodology provides a facile route to difluoroalkyl-substituted chiral isoindolinones bearing a quaternary stereogenic center in high yields and up to 96% enantioselectivity.

中文翻译:

手性螺环磷酸催化曼尼希型反应对映选择性合成二氟烷基化异吲哚啉酮

已经开发了由手性螺环磷酸催化的原位生成的环状酮亚胺与二氟烯氧基硅烷的对映选择性曼尼希型反应。该方法为以高产率和高达 96% 的对映选择性获得带有季立体中心的二氟烷基取代的手性异吲哚酮提供了一条简便的途径。
更新日期:2020-09-29
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