This study presents a simple and straightforward method for the preparation of aqueous-based stable polysaccharide-metal oxide nanoparticles composites — composed of carboxymethyl cellulose (CMC) and titanium dioxide nanoparticles (TiO₂ NPs), and their interaction with the cellulose surface, is presented. Using a combination of anionic polysaccharide CMC as a stabilizer agent and ultrasound probe sonication technique as an agitation tool, a highly stable dispersion of CMC/TiO₂ NPs composites is prepared in water, with and without the presence of calcium chloride electrolyte, at various pH values. The results of the dynamic light scattering and the zeta-potential measurements showed that the quality, the stability of the dispersions and the hydrodynamic radius of the particles (ca, 200–300 nm) remain well-preserved for several weeks under normal storage conditions. The transmission electron microscope revealed that the morphology and size of the dry particles size (ca. 25–50 nm) remain unchanged and are not influenced by the addition of the stabilizer CMC, the electrolyte or the pH value of the solution. The presence of electrolyte and the low pH of the dispersions strongly favored an irreversible and enhanced deposition of CMC/TiO₂ NPs on cellulose surface as showed by a quartz crystal microbalance with dissipation. A linear correlation between the concentration of CMC and the adsorbed mass of polymer and NPs, and the water content of the adsorbed layers is observed. X-ray photoelectron spectroscopy and atomic force microscopy are combined to prove the successful immobilization of polymer and NPs on the cellulose surface. The knowledge gained from this study can be extended not only for the stabilization of various metal oxide nanoparticles but also for the development of green polymer/NPs composites, that may have the potential to be used as functional coatings in biomedical (e.g. wound dressing) applications.

这项研究提出了一种简单，直接的方法来制备水基稳定的多糖-金属氧化物纳米颗粒复合材料，该复合材料由羧甲基纤维素（CMC）和二氧化钛纳米颗粒（TiO ₂ NPs）组成，并与纤维素表面相互作用。 。通过使用阴离子多糖CMC作为稳定剂和超声探针超声处理技术作为搅拌工具，可以在各种pH下在有或无氯化钙电解质存在的情况下，在水中制备高度稳定的CMC / TiO ₂ NPs复合材料分散体。价值观。动态光散射和ζ电势测量的结果表明，粒子的质量，分散体的稳定性和流体动力学半径（大约200-300 nm）在正常存储条件下可保存数周。透射电子显微镜显示干颗粒尺寸（约25–50 nm）的形态和尺寸保持不变，不受稳定剂CMC，电解质或溶液pH值的影响。电解质的存在和分散液的低pH值强烈促进了不可逆和增强的CMC / TiO ₂沉积石英表面微量天平随耗散显示出纤维素表面上的NP。观察到CMC的浓度与聚合物和NPs的吸附质量以及吸附层的水含量之间的线性相关性。X射线光电子能谱和原子力显微镜相结合，证明了聚合物和NPs在纤维素表面上的成功固定。从这项研究中获得的知识不仅可以扩展到各种金属氧化物纳米颗粒的稳定化，还可以扩展到绿色聚合物/ NPs复合材料的开发，这可能具有在生物医学（例如伤口敷料）应用中用作功能性涂层的潜力。 。