Abstract A novel series of 1,3,4-oxadiazole fused tetrazole amide derivatives (11a-j) were designed, synthesized and evaluated for their anticancer activities against three human cancer cell lines such as . Among them, compounds 11b, 11c, 11d, 11h and 11j were exhibit more potent anticancer activity than positive control. Among them, compound 11c showed potent anticancer activities against A549, MDA-MB-231 and MCF-7 cell lines with IC50 values of 1.02 µM, 1.34 µM and 0.31 µM respectively. This compound may be treat as drug lead one in cancer chemotherapy.

中文翻译：

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作为抗癌剂的 1,3,4-恶二唑稠合四唑酰胺衍生物的合成和生物学评价

摘要 设计、合成了一系列新型 1,3,4-恶二唑稠合四唑酰胺衍生物 (11a-j) 并评估了它们对三种人类癌细胞系的抗癌活性，例如 . 其中，化合物11b、11c、11d、11h和11j比阳性对照表现出更强的抗癌活性。其中，化合物 11c 对 A549、MDA-MB-231 和 MCF-7 细胞系显示出有效的抗癌活性，IC50 值分别为 1.02 µM、1.34 µM 和 0.31 µM。该化合物可作为癌症化疗中的药物先导之一。