A novel and efficient ammonium chloride catalyzed one-pot reaction of aromatic amines, aromatic aldehyde or respective imine with malonic esters was described. This cascade reaction affords the corresponding β-amino esters in good to excellent yield at room temperature in the presence of ethanol as solvent. The present methodology includes an inexpensive catalyst, easy work-up, mild reaction conditions, no side reaction and compatibility with the various substrates.

中文翻译：

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NH ₄ Cl催化合成β-氨基酯

描述了一种新颖而有效的氯化铵催化的芳香胺，芳香醛或相应的亚胺与丙二酸酯的一锅法反应。该级联反应在乙醇作为溶剂存在下于室温下以良好或优异的产率提供相应的β-氨基酯。本方法学包括廉价的催化剂，容易的后处理，温和的反应条件，无副反应以及与各种底物的相容性。