Four different hydroxycinnamic acid rhodamine B conjugates have been prepared and screened for their cytotoxic activity. In the sulforhodamine B (SRB) assay the majority of the conjugates displayed good cytotoxicity in the low μM range for different human tumor cell lines. Low EC₅₀ values were obtained especially for an apoptose-triggering cinnamic acid rhodamine conjugate 3 holding a piperazinyl spacer and a cinnamoyl moiety.

中文翻译：

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羟基肉桂酸若丹明B结合物的合成及细胞毒性评价

已经制备了四种不同的羟基肉桂酸罗丹明B缀合物，并筛选了它们的细胞毒性活性。在磺基罗丹明B（SRB）分析中，大多数缀合物在不同人类肿瘤细胞系的低μM范围内均显示出良好的细胞毒性。EC ₅₀值低，尤其是对于具有 哌嗪基间隔基和肉桂酰基部分的触发凋亡的肉桂酸若丹明缀合物3。