Unc-51-like kinase 4 (ULK4) is a pseudokinase conserved in most eukaryotes, yet ULK4 signaling mechanisms remain enigmatic. In this issue of Structure, Preuss and colleagues report a structure of the ATP-bound ULK4 pseudokinase domain, supported by proteomic analysis of the ULK4 interactome and in-depth evolutionary analysis of the intriguingULK4 pseudokinase domain.

中文翻译：

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惊叹于令人难以置信的ULK4

Unc-51样激酶4（ULK4）是在大多数真核生物中保守的假激酶，但ULK4信号传导机制仍然神秘。在本期《结构》中，Preuss及其同事报告了由ATP绑定的ULK4假激酶结构域的结构，该结构由对ULK4相互作用基因组的蛋白质组学分析和对有趣的ULK4假激酶结构域的深入进化分析所支持。