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A Tug-of-War Over Methionine
Cell Metabolism ( IF 29.0 ) Pub Date : 2020-11-03 , DOI: 10.1016/j.cmet.2020.10.016
Ke Xu , Amy Shyu , Ming O. Li

Nutrient acquisition and metabolism are integral components of cell growth, proliferation, and differentiation programs. In a recent study in Nature, Bian et al. (2020) revealed that cancer cells outcompete T cells for methionine uptake, resulting in diminished SAM production, attenuated H3K79 dimethylation, decreased STAT5 expression, and impaired T cell immunity to cancer.



中文翻译:

蛋氨酸的拔河比赛

营养素的获取和代谢是细胞生长,增殖和分化程序不可或缺的组成部分。在《自然》杂志的最新研究中,Bian等人。(2020)发现癌细胞在蛋氨酸吸收方面比T细胞更胜一筹,导致SAM产量减少,H3K79二甲基化减弱,STAT5表达降低以及T细胞对癌症的免疫力下降。

更新日期:2020-11-03
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