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Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production
Cell ( IF 64.5 ) Pub Date : 2020-11-03 , DOI: 10.1016/j.cell.2020.10.051
Yuezhou Chen 1 , Adam Zuiani 1 , Stephanie Fischinger 2 , Jyotsna Mullur 1 , Caroline Atyeo 2 , Meghan Travers 1 , Felipe J N Lelis 1 , Krista M Pullen 3 , Hannah Martin 1 , Pei Tong 1 , Avneesh Gautam 1 , Shaghayegh Habibi 1 , Jillian Bensko 1 , Deborah Gakpo 1 , Jared Feldman 2 , Blake M Hauser 2 , Timothy M Caradonna 2 , Yongfei Cai 4 , John S Burke 2 , Junrui Lin 1 , James A Lederer 5 , Evan Christopher Lam 2 , Christy L Lavine 6 , Michael S Seaman 6 , Bing Chen 7 , Aaron G Schmidt 8 , Alejandro Benjamin Balazs 8 , Douglas A Lauffenburger 9 , Galit Alter 8 , Duane R Wesemann 10
Affiliation  

Antibodies are key immune effectors that confer protection against pathogenic threats. The nature and longevity of the antibody response to SARS-CoV-2 infection are not well defined. We charted longitudinal antibody responses to SARS-CoV-2 in 92 subjects after symptomatic COVID-19. Antibody responses to SARS-CoV-2 are unimodally distributed over a broad range, with symptom severity correlating directly with virus-specific antibody magnitude. Seventy-six subjects followed longitudinally to ∼100 days demonstrated marked heterogeneity in antibody duration dynamics. Virus-specific IgG decayed substantially in most individuals, whereas a distinct subset had stable or increasing antibody levels in the same time frame despite similar initial antibody magnitudes. These individuals with increasing responses recovered rapidly from symptomatic COVID-19 disease, harbored increased somatic mutations in virus-specific memory B cell antibody genes, and had persistent higher frequencies of previously activated CD4+ T cells. These findings illuminate an efficient immune phenotype that connects symptom clearance speed to differential antibody durability dynamics.



中文翻译:

COVID-19 快速治疗者维持抗 SARS-CoV-2 抗体生产

抗体是关键的免疫效应物,可提供针对病原体威胁的保护。针对 SARS-CoV-2 感染的抗体反应的性质和持续时间尚不明确。我们绘制了 92 名出现症状的 COVID-19 受试者对 SARS-CoV-2 的纵向抗体反应图。对 SARS-CoV-2 的抗体反应在广泛范围内呈单峰分布,症状严重程度与病毒特异性抗体强度直接相关。76 名受试者纵向随访约 100 天,在抗体持续时间动态方面表现出明显的异质性。大多数个体的病毒特异性 IgG 大幅衰减,而不同的亚群在同一时间范围内抗体水平稳定或增加,尽管初始抗体量相似。这些反应增加的个体从有症状的 COVID-19 疾病中迅速恢复,病毒特异性记忆 B 细胞抗体基因的体细胞突变增加,并且先前激活的 CD4 + T 细胞的频率持续较高。这些发现阐明了一种有效的免疫表型,将症状清除速度与差异抗体耐久性动态联系起来。

更新日期:2020-12-10
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