Abstract

Four new monoterpenoid indole alkaloids, bousmekines A-D (1–4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC₅₀ values of 0.8–7.4 μM.

Graphic Abstract

中文翻译：

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Bousmekines AE，来自两个Bousigonia物种的新生物碱：B.angustifolia和B. mekongensis

摘要

四个新的单萜吲哚生物碱，bousmekines AD（1 - 4），以及一个新的吡喃并吡啶生物碱，bousmekine E（5），是从的树枝和叶子中分离Bousigonia沙枣和Bousigonia mekongensis。通过结合MS，NMR，ECD计算和单晶X射线衍射分析，阐明了它们的结构，包括绝对构型。化合物2是一种以稀有氯原子为特征的棕褐色型MIA，而化合物5则具有新颖的吡喃吡啶部分。评估了它们对几种人类癌细胞系的细胞毒性，化合物1对IC表现出明显的细胞毒性_50个值，为0.8–7.4μM。

图形摘要