Exercise interventions have been considered to be an effective treatment for drug addiction. However, there is little dirct evidence that exercise affects brain activity in individuals afftected by drug addiction. Therefore, the aim of the present study was to investigate the effects of different exercise programs on detoxification. Cognitive recovery with 64-channel electroencephalography (EEG) recordings was obtained before and after three months of daily aerobic and anaerobic exercise. A total of 63 subjects with methamphetamine addiction were recruited and randomly divided into three groups for cognitive study in four behavioral states: an anaerobic resistance treatment group, an aerobic cycling treatment group and a control group. In addition, four behavioral states were examined: eyes-closed and eyes-open resting states, and exploratory behavior states following either drug- or neutral-cue exposure. Over a 12-week period,the alpha block ratio in the control group showed a slight decrease, while clear increases were observed in the resistance exercise and cycling treatment groups, particularly under the frontal and temporal regions in the eyes-open and drug-cue conditions. The major EEG activity frequency in the resistance treatment group during the drug-cue behavior task decreased compared with the frequencies of the cycling exercise and control groups. Meanwhile, the power of higher brain rhythms in the resistance treatment group was increased. Finally, the brain alpha wave left-lateralization index from EEG recording sites, F1–F2, in the resistance and cycling treatment groups under the eyes-closed condition positively decreased, while the control groups only showed slight decreases. Taken together, these results suggest that different types of exercise may induce distince and different positive therapeutic effects to facilitate detoxification.

运动干预被认为是治疗药物成瘾的有效方法。然而，几乎没有直接证据表明运动会影响受毒瘾影响的个体的大脑活动。因此，本研究的目的是调查不同运动计划对解毒的影响。在每天有氧和无氧运动三个月之前和之后，通过 64 通道脑电图 (EEG) 记录获得认知恢复。共招募了 63 名甲基苯丙胺成瘾受试者，随机分为三组进行认知研究，分为四种行为状态：厌氧抵抗治疗组、有氧循环治疗组和对照组。此外，还检查了四种行为状态：闭眼和睁眼休息状态，以及在药物或中性线索暴露后的探索性行为状态。12周内，对照组的α阻滞比略有下降，而抗阻运动和自行车治疗组明显增加，尤其是在睁眼和药物提示的额叶和颞叶区域条件。与自行车运动组和对照组相比，药物提示行为任务期间阻力治疗组的主要脑电图活动频率降低。同时，抵抗治疗组更高的脑节律的力量增加了。最后，在闭眼条件下，阻力和循环治疗组的脑电图记录点 F1-F2 的脑 α 波左偏指数正下降，而对照组仅略有下降。总之，这些结果表明，不同类型的运动可能会产生不同的积极治疗效果，以促进排毒。