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Nanoplatform-based cascade engineering for cancer therapy
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2020-10-28 , DOI: 10.1039/d0cs00607f
Jiajie Chen 1, 2, 3, 4, 5 , Yufang Zhu 1, 2, 3, 4, 5 , Chengtie Wu 1, 2, 3, 4, 5 , Jianlin Shi 1, 2, 3, 4, 5
Affiliation  

Various therapeutic techniques have been studied for treating cancer precisely and effectively, such as targeted drug delivery, phototherapy, tumor-specific catalytic therapy, and synergistic therapy, which, however, evoke numerous challenges due to the inherent limitations of these therapeutic modalities and intricate biological circumstances as well. With the remarkable advances of nanotechnology, nanoplatform-based cascade engineering, as an efficient and booming strategy, has been tactfully introduced to optimize these cancer therapies. Based on the designed nanoplatforms, pre-supposed cascade processes could be triggered under specific conditions to generate/deliver more therapeutic species or produce stronger tumoricidal effects inside tumors, aiming to achieve cancer therapy with increased anti-tumor efficacy and diminished side effects. In this review, the recent advances in nanoplatform-based cascade engineering for cancer therapy are summarized and discussed, with an emphasis on the design of smart nanoplatforms with unique structures, compositions and properties, and the implementation of specific cascade processes by means of endogenous tumor microenvironment (TME) resources and/or exogenous energy inputs. This fascinating strategy presents unprecedented potential in the enhancement of cancer therapies, and offers better controllability, specificity and effectiveness of therapeutic functions compared to the corresponding single components/functions. In the end, challenges and prospects of such a burgeoning strategy in the field of cancer therapy will be discussed, hopefully to facilitate its further development to meet the personalized treatment demands.

中文翻译:

基于纳米平台的级联工程用于癌症治疗

为了精确有效地治疗癌症,人们已经研究了各种治疗技术,例如靶向药物递送,光疗,肿瘤特异性催化治疗和协同治疗,但是由于这些治疗方式的固有局限性以及复杂的生物学方法,这些技术引起了许多挑战。情况也是如此。随着纳米技术的显着进步,基于纳米平台的级联工程作为一种有效且蓬勃发展的策略,被巧妙地引入以优化这些癌症疗法。基于设计的纳米平台,可以在特定条件下触发预设的级联过程,以在肿瘤内部产生/提供更多的治疗物种或产生更强的杀肿瘤效果,旨在实现具有增强的抗肿瘤功效并减少副作用的癌症治疗。在这篇综述中,总结和讨论了基于纳米平台的癌症治疗级联工程的最新进展,重点是设计具有独特结构,组成和特性的智能纳米平台,以及通过内源性肿瘤实施特定级联过程的方法。微环境(TME)资源和/或外来能量输入。与相应的单个组件/功能相比,这种引人入胜的策略在增强癌症治疗方面展现了空前的潜力,并提供了更好的可控制性,特异性和治疗功能。最后,将讨论在癌症治疗领域中这种新兴策略的挑战和前景,希望能促进其进一步发展以满足个性化治疗需求。总结和讨论了基于纳米平台的癌症治疗级联工程的最新进展,重点是设计具有独特结构,组成和特性的智能纳米平台,以及通过内源性肿瘤微环境(TME)实施特定级联过程资源和/或外来能量输入。与相应的单个组件/功能相比,这种引人入胜的策略在增强癌症治疗方面展现了空前的潜力,并提供了更好的可控制性,特异性和治疗功能。最后,将讨论在癌症治疗领域中这种新兴策略的挑战和前景,希望能促进其进一步发展以满足个性化治疗需求。总结和讨论了基于纳米平台的癌症治疗级联工程的最新进展,重点是设计具有独特结构,组成和特性的智能纳米平台,以及通过内源性肿瘤微环境(TME)实施特定级联过程资源和/或外来能量输入。与相应的单个组件/功能相比,这种引人入胜的策略在增强癌症治疗方面展现了空前的潜力,并提供了更好的可控制性,特异性和治疗功能。最后,将讨论在癌症治疗领域中这种新兴策略的挑战和前景,希望能促进其进一步发展以满足个性化治疗需求。
更新日期:2020-11-03
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