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Biological concepts for catalysis and reactivity: empowering bioinspiration
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2020-10-27 , DOI: 10.1039/d0cs00914h Agnideep Das 1, 2, 3, 4, 5 , Cheriehan Hessin 1, 2, 3, 4, 5 , Yufeng Ren 5, 6, 7, 8, 9 , Marine Desage-El Murr 1, 2, 3, 4, 5
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2020-10-27 , DOI: 10.1039/d0cs00914h Agnideep Das 1, 2, 3, 4, 5 , Cheriehan Hessin 1, 2, 3, 4, 5 , Yufeng Ren 5, 6, 7, 8, 9 , Marine Desage-El Murr 1, 2, 3, 4, 5
Affiliation
Biological systems provide attractive reactivity blueprints for the design of challenging chemical transformations. Emulating the operating mode of natural systems may however not be so easy and direct translation of structural observations does not always afford the anticipated efficiency. Metalloenzymes rely on earth-abundant metals to perform an incredibly wide range of chemical transformations. To do so, enzymes in general have evolved tools and tricks to enable control of such reactivity. The underlying concepts related to these tools are usually well-known to enzymologists and bio(inorganic) chemists but may be a little less familiar to organometallic chemists. So far, the field of bioinspired catalysis has greatly focused on the coordination sphere and electronic effects for the design of functional enzyme models but might benefit from a paradigm shift related to recent findings in biological systems. The goal of this review is to bring these fields closer together as this could likely result in the development of a new generation of highly efficient bioinspired systems. This contribution covers the fields of redox-active ligands, entatic state reactivity, energy conservation through electron bifurcation, and quantum tunneling for C–H activation.
中文翻译:
催化和反应的生物学概念:赋予生物灵感
生物系统为具有挑战性的化学转化设计提供了有吸引力的反应蓝图。然而,模拟自然系统的运行模式可能并不那么容易,直接转换结构观测值并不总是能提供预期的效率。金属酶依赖于地球上丰富的金属来执行范围广泛的化学转化。为此,酶通常已经进化出能够控制这种反应性的工具和技巧。与这些工具相关的基本概念通常是酶学家和生物(无机)化学家众所周知的,但有机金属化学家可能不太熟悉。至今,受生物启发的催化领域已大大集中于功能酶模型设计的协调领域和电子效应,但可能会受益于与生物系统最新发现有关的范式转变。这次审查的目的是使这些领域更加紧密,因为这可能会导致新一代高效生物启发系统的开发。这一贡献涵盖了氧化还原活性配体,焓态反应性,通过电子分叉守恒的能量以及用于CH活化的量子隧穿等领域。
更新日期:2020-11-03
中文翻译:
催化和反应的生物学概念:赋予生物灵感
生物系统为具有挑战性的化学转化设计提供了有吸引力的反应蓝图。然而,模拟自然系统的运行模式可能并不那么容易,直接转换结构观测值并不总是能提供预期的效率。金属酶依赖于地球上丰富的金属来执行范围广泛的化学转化。为此,酶通常已经进化出能够控制这种反应性的工具和技巧。与这些工具相关的基本概念通常是酶学家和生物(无机)化学家众所周知的,但有机金属化学家可能不太熟悉。至今,受生物启发的催化领域已大大集中于功能酶模型设计的协调领域和电子效应,但可能会受益于与生物系统最新发现有关的范式转变。这次审查的目的是使这些领域更加紧密,因为这可能会导致新一代高效生物启发系统的开发。这一贡献涵盖了氧化还原活性配体,焓态反应性,通过电子分叉守恒的能量以及用于CH活化的量子隧穿等领域。