Lymphoma is the most complicated cancer that can be divided into several tens of subtypes. It may occur in any part of body that has lymphocytes, and is closely correlated with diverse environmental factors such as the ionizing radiation, chemocarcinogenesis, and virus infection. All the environmental factors affect the lymphoma through genes. Identifying pathogenic genes for lymphoma is consequently an essential task to understand its complexity in a unified framework. In this paper, we propose a new method to expose high-confident edges in gene regulatory networks (GRNs) for a total of 32 organs, called Filtered GRNs (f-GRNs), comparison of which gives us a proper reference for the Lymphoma, i.e. the B-lymphocytes cells, whose f-GRN is closest with that for the Lymphoma. By using the Gene Ontology and Biological Process analysis we display the differences of the two networks’ hubs in biological functions. Matching with the Genecards shows that most of the hubs take part in the genetic information transmission and expression, except a specific gene of Retinoic Acid Receptor Alpha (RARA) that encodes the retinoic acid receptor. In the lymphoma, the genes in the RARA ego-network are involved in two cancer pathways, and the RARA is present only in these cancer pathways. For the lymphoid B cells, however, the genes in the RARA ego-network do not participate in cancer-related pathways.

中文翻译：

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比较基因调控网络以识别淋巴瘤的致病基因

淋巴瘤是最复杂的癌症，可分为几十个亚型。它可能发生在身体任何有淋巴细胞的部位，与电离辐射、化学致癌、病毒感染等多种环境因素密切相关。所有的环境因素都通过基因影响淋巴瘤。因此，识别淋巴瘤的致病基因是在统一框架中了解其复杂性的一项基本任务。在本文中，我们提出了一种新方法，可以在总共 32 个器官的基因调控网络 (GRN) 中暴露高置信度边缘，称为过滤 GRN (f-GRN)，其比较为我们提供了淋巴瘤的适当参考，即 B 淋巴细胞，其 f-GRN 与淋巴瘤的 f-GRN 最接近。通过使用基因本体和生物过程分析，我们展示了两个网络中心在生物学功能上的差异。与Genecards匹配表明，除了编码视黄酸受体的视黄酸受体α（RARA）的特定基因外，大多数中枢都参与了遗传信息的传递和表达。在淋巴瘤中，RARA 自我网络中的基因涉及两种癌症途径，而 RARA 仅存在于这些癌症途径中。然而，对于淋巴样 B 细胞，RARA 自我网络中的基因不参与癌症相关的途径。除了编码视黄酸受体的视黄酸受体 Alpha (RARA) 的特定基因。在淋巴瘤中，RARA 自我网络中的基因涉及两种癌症途径，而 RARA 仅存在于这些癌症途径中。然而，对于淋巴样 B 细胞，RARA 自我网络中的基因不参与癌症相关的途径。除了编码视黄酸受体的视黄酸受体 Alpha (RARA) 的特定基因。在淋巴瘤中，RARA 自我网络中的基因涉及两种癌症途径，而 RARA 仅存在于这些癌症途径中。然而，对于淋巴样 B 细胞，RARA 自我网络中的基因不参与癌症相关的途径。