Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex maintains gene transcriptional repression and plays an essential role in the maintenance of cellular identity as well as normal organismal development. The activity of PRC2, including its genomic targeting and catalytic activity, is controlled by various signals. Recent studies have revealed that these signals involve cis chromatin features, PRC2 facultative subunits and post-translational modifications (PTMs) of PRC2 subunits. Overall, these findings have provided insight into the biochemical signals directing PRC2 function, although many mysteries remain.

中文翻译：

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PRC2的翻译后修饰：指示其活动的信号

聚梳抑制复合物2（PRC2）是一种染色质修饰酶，可催化组氨酸H3在赖氨酸27（H3K27me1 / 2/3）处的甲基化。该复合物维持基因转录抑制，并在维持细胞身份以及正常生物发育中起重要作用。PRC2的活性，包括其基因组靶向和催化活性，受各种信号控制。最近的研究表明，这些信号涉及顺式染色质特征，PRC2兼性亚基和PRC2亚基的翻译后修饰（PTM）。总体而言，这些发现为指导PRC2功能的生化信号提供了见识，尽管仍有许多谜团。