Researches on the principle of human red blood cell’s (RBC) injuring and judgment basis play an important role in decreasing the hemolysis in a blood pump. In the current study, the judgment of hemolysis in a blood pump study was through some experiment data and empirical formula. The paper forms a criterion of RBC’s mechanical injury in the aspect of RBC’s free energy. First, the paper introduces the nonlinear spring network model of RBC in the frame of immersed boundary-lattice Boltzmann method (IB-LBM). Then, the shape, free energy, and time needed for erythrocyte to be shorn in different shear flow and impacted in different impact flow are simulated. Combining existing research on RBC’s threshold limit for hemolysis in shear and impact flow with this paper’s, the RBC’s free energy of the threshold limit for hemolysis is found to be  J. The threshold impact velocity of RBC for hemolysis is 8.68 m/s. The threshold value of RBC can be used for judgment of RBC’s damage when the RBC is having a complicated flow of blood pumps such as coupling effect of shear and impact flow. According to the change law of RBC’s free energy in the process of being shorn and impacted, this paper proposed a judging criterion for hemolysis when the RBC is under the coupling effect of shear and impact based on the increased free energy of RBC.

中文翻译：

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浸入边界-格子Boltzmann方法研究人红细胞的阈值自由能对溶血和剪切与碰撞的耦合作用的损伤

对人体红细胞损伤原理的研究和判断依据在减少血泵溶血中起着重要作用。在当前的研究中，对血泵研究中溶血的判断是通过一些实验数据和经验公式得出的。本文从红细胞的自由能角度出发，对红细胞的机械伤害提出了标准。首先，在沉浸边界格子玻尔兹曼方法（IB-LBM）的框架下，介绍了RBC的非线性弹簧网络模型。然后，模拟了在不同的剪切流中刺入红细胞并在不同的冲击流中进行冲击所需的形状，自由能和时间。结合现有的关于RBC在剪切流和冲击流中溶血的极限值的研究与本文的研究，发现RBC的溶血阈值的自由能为 J. RBC溶血的阈值撞击速度为8.68 m / s。当红细胞具有复杂的血泵流量（例如剪切力和冲击流的耦合效应）时，红细胞的阈值可用于判断红细胞的损害。根据红细胞在受到冲击和撞击过程中自由能的变化规律，基于红细胞自由能的增加，提出了红细胞在剪切和冲击耦合作用下的溶血判断标准。