Plasma polymers derived from oxazoline precursors present a range of versatile properties that is fueling their use as biomaterials. However, coatings deposited from commonly used methyl and ethyl oxazoline precursors can be sensitive to the plasma deposition conditions. In this work, we used various spectroscopic methods (ellipsometry, x-ray photoelectron spectroscopy, and time of flight secondary ion mass spectrometry) and cell viability assays to evaluate the transferability of deposition conditions from the original plasma reactor developed by Griesser to a new wider, reactor designed for upscaled biosensors applications. The physicochemical properties, reactivity, and biocompatibility of films deposited from 2-isopropenyl-2-oxazoline were investigated. Thanks to the availability of an unsaturated pendant group, the coatings obtained from this oxazoline precursor are more stable and reproducible over a range of deposition conditions while retaining reactivity toward ligands and biomolecules. This study identified films deposited at 20 W and 0.012 mbar working pressure as being the best suited for biosensor applications.

中文翻译：

---

用于生物传感器应用的 2-isopropenyl-2-oxazoline 等离子沉积的功能性纳米薄膜。

衍生自恶唑啉前体的等离子体聚合物具有一系列通用特性，推动了它们作为生物材料的应用。然而，由常用的甲基和乙基恶唑啉前体沉积的涂层可能对等离子体沉积条件敏感。在这项工作中，我们使用了各种光谱方法（椭圆光度法、X 射线光电子能谱法和飞行时间二次离子质谱法）和细胞活力测定来评估沉积条件从 Griesser 开发的原始等离子体反应器到新的更广泛的反应器的可转移性。 , 反应器设计用于升级生物传感器应用。研究了由 2-isopropenyl-2-oxazoline 沉积的薄膜的物理化学性质、反应性和生物相容性。由于不饱和悬垂基团的可用性，从这种恶唑啉前体获得的涂层在一系列沉积条件下更加稳定和重现，同时保持对配体和生物分子的反应性。该研究确定在 20 W 和 0.012 mbar 工作压力下沉积的薄膜最适合生物传感器应用。