Tumor-specific changes in DNA methylation are both acquired actively through transcription-coupled processes and passively accumulated over time. Analysis across B cell malignancies now shows that these changes provide insight into the cellular origin as well as the proliferative history of tumors and thereby have diagnostic value and prognostic value, respectively.

中文翻译：

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B细胞肿瘤的时钟

DNA甲基化的肿瘤特异性变化既是通过转录偶联过程主动获得的，也是随着时间的推移被动积累的。现在对 B 细胞恶性肿瘤的分析表明，这些变化提供了对细胞起源和肿瘤增殖史的深入了解，因此分别具有诊断价值和预后价值。