Abstract

Coronavirus disease (COVID-19) is an infectious disease caused by a new virus that causes respiratory illness. Older adults and individuals who have pre-existing chronic medical conditions are at higher risk for more serious complications from COVID-19. Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, cardiovascular events and associated comorbidities, which are the main causes of severe clinical complications in COVID-19 patients. Considering the defensive role of vitamin D, mediated through modulation of the innate and adaptive immune system as well as inhibition of the Renin Angiotensin System (RAS), vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals.

摘要

冠状病毒病 (COVID-19) 是由引起呼吸道疾病的新型病毒引起的传染病。老年人和已有慢性病的人因 COVID-19 患上更严重并发症的风险更高。维生素 D 缺乏症是由于肺损伤和急性呼吸窘迫综合征（ARDS）以及糖尿病、心血管事件和相关合并症的风险增加，这些是 COVID-19 患者严重临床并发症的主要原因。考虑到维生素 D 的防御作用，通过调节先天性和适应性免疫系统以及抑制肾素血管紧张素系统 (RAS) 介导，补充维生素 D 可能会增强 COVID-19 患者的免疫系统并降低疾病的严重程度在缺乏维生素 D 的个体中。