A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.

中文翻译：

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从胞苷到 MK-4482 (EIDD-2801) 的简洁路线：第 2 部分

开发了一条通往 MK-4482 的新路线。该路线用更容易获得且更便宜的胞苷代替尿苷。化学转化使用低成本、简单的试剂，收率从17%提高到44%。从最长的线性序列中删除了一个步骤，如果 MK-4482 成为可行的药物物质，这些进步有望扩大对它的访问。