Catalytic generation of reactive oxygen species has been developed as a promising methodology for tumor therapy. Direct O₂^•− production from intratumor oxygen exhibits exceptional tumor therapeutic efficacy. Herein, this therapy strategy is demonstrated by a pH‐responsive hybrid of porous CeO₂ nanorods and sodium polystyrene sulfonate that delivers high oxidative activity for O₂^•− generation within acidic tumor microenvironments for chemodynamic therapy and only limited oxidative activity in neutral media to limit damage to healthy organs. The hydrated polymer–nanorod hybrids with large hydrodynamic diameters form nanoreactors that locally trap oxygen and biological substrates inside and improve the charge transfer between the catalysts and substrates in the tumor microenvironment, leading to enhanced catalytic O₂^•− production and consequent oxidation. Together with successful in vitro and in vivo experiments, these data show that the use of hybrids provides a compelling opportunity for the delivery selective chemodynamic tumor therapy.

中文翻译：

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pH响应型聚合物CeO2杂化物可催化产生氧化应激以进行肿瘤治疗。

活性氧物种的催化生成已被开发为用于肿瘤治疗的有前途的方法。肿瘤内氧气直接产生O ₂ ^•−表现出卓越的肿瘤治疗功效。本文中，这种治疗策略通过多孔CeO ₂纳米棒和聚苯乙烯磺酸钠的pH响应混合物得到证明，该混合物对O ₂ ^•-具有高氧化活性可以在酸性肿瘤微环境中产生化学动力学疗法，并且只能在中性介质中限制氧化活性，以限制对健康器官的损害。具有大流体动力学直径的水合聚合物-纳米纤维杂化物形成纳米反应器，该反应器将氧和生物底物局部捕集到内部，并改善了肿瘤微环境中催化剂和底物之间的电荷转移，从而提高了催化O ₂ ^•生成和随后的氧化作用。连同成功的体外和体内实验，这些数据表明，使用杂合体为递送选择性化学动力学肿瘤治疗提供了令人信服的机会。