Several months after the sudden emergence of SARS‐CoV‐2 and COVID‐19, the understanding of the appropriate host immune response to a virus totally unknown of human immune surveillance is still of major importance. By international definition, COVID‐19 falls in the scope of septic syndromes (organ dysfunction due to dysregulated host response to an infection) in which immunosuppression is a significant driver of mortality. Sepsis‐induced immunosuppression is mostly defined and monitored by the measurement of decreased expression of HLA‐DR molecules on circulating monocytes (mHLA‐DR). In this interim review, we summarize the first mHLA‐DR results in COVID‐19 patients. In critically ill patients, results homogenously indicate a decreased mHLA‐DR expression, which, along with profound lymphopenia and other functional alterations, is indicative of a status of immunosuppression. © 2020 International Society for Advancement of Cytometry

中文翻译：

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流式细胞术检测COVID-19患者单核细胞HLA-DR：中期审查

在SARS‐CoV‐2和COVID‐19突然出现后的几个月，了解对宿主免疫完全未知的病毒的适当宿主免疫反应的理解仍然非常重要。根据国际定义，COVID-19属于败血症综合征（由于感染宿主反应失调导致器官功能障碍）的范围，其中免疫抑制是导致死亡的重要因素。脓毒症诱导的免疫抑制作用主要是通过测量循环单核细胞（mHLA-DR）上HLA-DR分子表达下降来定义和监测。在此中期审查中，我们总结了COVID-19患者的首批mHLA‐DR结果。在重症患者中，结果同质表明mHLA-DR表达下降，这与严重的淋巴细胞减少症和其他功能改变一起，指示免疫抑制状态。©2020国际细胞计数学会