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Advances in Magnetic Nanoparticle‐Mediated Cancer Immune‐Theranostics
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-01 , DOI: 10.1002/adhm.202001451
Hung‐Wei Cheng, Hsin‐Yi Tsao, Chih‐Sheng Chiang, San‐Yuan Chen

Cancer immunotherapy is a cutting‐edge strategy that eliminates cancer cells by amplifying the host's immune system. However, the low response rate and risks of inducing systemic toxicity have raised uncertainty in the treatment. Magnetic nanoparticles (MNPs) as a versatile theranostic tool can be used to target delivery of multiple immunotherapeutics and monitor cell/tissue responses. These capabilities enable the real‐time characterization of the factors that contribute to immunoactivity so that future treatments can be optimized. The magnetic properties of MNPs further allow the implementation of magnetic navigation and magnetic hyperthermia for boosting the efficacy of immunotherapy. The multimodal approach opens an avenue to induce robust immune responses, minimize safety issues, and monitor immune activities simultaneously. Thus, the object of this review is to provide an overview of the burgeoning fields and to highlight novel technologies for next‐generation immunotherapy. The review further correlates the properties of MNPs with the latest treatment strategies to explore the crosstalk between magnetic nanomaterials and the immune system. This comprehensive review of MNP‐derived immunotherapy covers the obstacles and opportunities for future development and clinical translation.

中文翻译:

磁性纳米粒子介导的癌症免疫治疗的进展

癌症免疫疗法是通过扩大宿主的免疫系统消除癌细胞的前沿策略。但是,低响应率和诱发全身毒性的风险增加了治疗的不确定性。磁性纳米颗粒(MNP)作为一种通用的治疗方法,可用于靶向多种免疫治疗剂的递送并监测细胞/组织反应。这些功能可以实时表征促成免疫活性的因素,从而可以优化未来的治疗方法。MNP的磁性进一步允许磁导航和磁热疗的实施,以提高免疫疗法的功效。多模式方法为诱导强大的免疫反应,最小化安全性问题并同时监控免疫活动开辟了一条途径。从而,本文的目的是概述新兴领域,并重点介绍用于下一代免疫疗法的新技术。审查进一步将MNPs的特性与最新的治疗策略相关联,以探索磁性纳米材料与免疫系统之间的串扰。对MNP衍生的免疫疗法的全面综述涵盖了未来开发和临床翻译的障碍和机遇。
更新日期:2021-01-06
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