Eating disorders are life-interrupting psychiatric conditions with high morbidity and mortality, yet the basic mechanisms underlying these conditions are understudied compared with other psychiatric disorders. In this opinion, we suggest that recent knowledge gleaned from genomic and neuroimaging investigations of eating disorders in humans presents a rich opportunity to sharpen animal models of eating disorders and to identify neural mechanisms that contribute to the risk and maintenance of these conditions. Our article reflects the state of the science, with a primary focus on anorexia nervosa (AN) and binge-eating behavior, and encourages further study of all conditions categorized under feeding and eating disorders.

中文翻译：

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推进饮食失调研究的替代框架

饮食失调是一种具有高发病率和死亡率的中断生命的精神疾病，但与其他精神疾病相比，这些疾病的基本机制尚未得到充分研究。在这个观点中，我们建议从人类饮食失调的基因组和神经影像学调查中收集到的最新知识提供了丰富的机会来改善饮食失调的动物模型，并确定导致这些疾病风险和维持的神经机制。我们的文章反映了科学现状，主要关注神经性厌食症 (AN) 和暴食行为，并鼓励进一步研究归类为喂养和进食障碍的所有条件。