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A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
Trends in Immunology ( IF 16.8 ) Pub Date : 2020-11-02 , DOI: 10.1016/j.it.2020.10.012 Ligong Lu , Hui Zhang , Danielle J. Dauphars , You-Wen He
中文翻译:
白介素10在COVID-19发病机制中的潜在作用。
更新日期:2020-12-30
Trends in Immunology ( IF 16.8 ) Pub Date : 2020-11-02 , DOI: 10.1016/j.it.2020.10.012 Ligong Lu , Hui Zhang , Danielle J. Dauphars , You-Wen He
A unique feature of the cytokine storm in coronavirus disease 2019 (COVID-19) is the dramatic elevation of interleukin 10 (IL-10). This was thought to be a negative feedback mechanism to suppress inflammation. However, several lines of clinical evidence suggest that dramatic early proinflammatory IL-10 elevation may play a pathological role in COVID-19 severity.
中文翻译:
白介素10在COVID-19发病机制中的潜在作用。
2019年冠状病毒病(COVID-19)中细胞因子风暴的独特特征是白介素10(IL-10)的急剧升高。认为这是抑制炎症的负反馈机制。但是,一些临床证据表明,早期促炎性IL-10急剧升高可能在COVID-19严重性中起病理作用。