The complexation behavior of peracetylated β-cyclodextrin (PA-β-CD) in supercritical carbon dioxide (scCO₂) was studied using ibuprofen as a model compound. The complex was studied by differential scanning calorimetry, infrared, raman and nuclear magnetic resonance spectroscopy, scanning electron microscopy and dissolution study. Differential scanning calorimetry showed that ibuprofen loses its crystalline form, evidencing the complexation at molecular level, which was confirmed by scanning electron microscopy, infrared and raman. Nuclear magnetic resonance spectroscopy showed shift of peaks for ibuprofen and, for PA-β-CD, it showed changes in coupling constants for H1 and H6’ and did not show shifts of peaks for H3 and H5, but for H6’, showing that the complexation occurs, but not by inclusion; it also showed that the conformation of PA-β-CD is compatible to the one it assumes in scCO₂. Moreover, dissolution study showed that this kind of complex can be used for controlled drug release.

过乙酰化β-环糊精（PA-β-CD）在超临界二氧化碳（scCO ₂使用布洛芬作为模型化合物进行了研究）。通过差示扫描量热法，红外，拉曼和核磁共振波谱，扫描电子显微镜和溶解研究研究了该络合物。差示扫描量热法显示布洛芬失去其晶体形式，证明在分子水平上的络合，这通过扫描电子显微镜，红外和拉曼证实。核磁共振波谱显示布洛芬的峰发生位移，而PA-β-CD的峰显示H1和H6'的耦合常数发生变化，而H3和H5的峰未发生变化，但H6'的峰发生变化。发生复合，但不是通过包含；它也表明PA-β-CD的构象与其在scCO _2中假定的构象是相容的。此外，溶出度研究表明这种复合物可用于药物的控制释放。