Abstract Stem bark of Sterculia setigera Delile, family Sterculiaceae, is used in traditional medicine in Sudan and other African countries to treat various diseases. This study aimed to investigate the chemical constituents, antioxidant, enzyme inhibition and antiproliferative activities of stem bark extracts and an isolated compound. Compounds were extracted using hexane and dichloromethane: ethanol (DE) (1:1). Chromatographic techniques were performed to characterize the phenolic compounds. We isolated lupeol as a bioactive compound in S. setigera from DE extract. The antioxidant and enzyme inhibitory properties of each extract were evaluated. The antiproliferative activity of the DE extract was determined. Results showed that five known compounds namely; procyanidins as dimer B, trimer C1 and tetramer, 3,4-dimethoxyphenol s-D-apiofuranosyl (1″→6″)- s -D-glucopyranoside and (+)- catechin were identified or tentatively elucidated, in addition to the isolation and characterization of lupeol. DE extract showed significantly (p

中文翻译：

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非洲药用树 Sterculia setigera Delile 茎皮化学成分及生物活性

摘要 梧桐科Sterculia setigera Delile的茎皮在苏丹和其他非洲国家的传统医学中用于治疗各种疾病。本研究旨在研究茎皮提取物和分离化合物的化学成分、抗氧化、酶抑制和抗增殖活性。使用己烷和二氯甲烷: 乙醇 (DE) (1:1) 萃取化合物。使用色谱技术来表征酚类化合物。我们从 DE 提取物中分离出羽扇豆醇作为 S. setigera 中的生物活性化合物。评估了每种提取物的抗氧化和酶抑制特性。测定了 DE 提取物的抗增殖活性。结果表明，五种已知化合物分别是；原花青素作为二聚体 B、三聚体 C1 和四聚体 3，除了羽扇豆醇的分离和表征外，还鉴定或初步阐明了 4-二甲氧基苯酚 sD-吡喃呋喃糖基 (1″→6″)-s-D-吡喃葡萄糖苷和 (+)- 儿茶素。DE 提取物显示显着 (p