Background

Hypoglycaemia, the frightening condition of low blood sugar, is a common occurrence in people with diabetes using insulin therapy. The idea of protecting against hypoglycaemia by engineering an insulin preparation that can auto-adjust its biological activity to fluctuating blood glucose levels has been pursued since the 1970’s, but despite thousands of publications, no system that works well enough for practical use has reached clinical practice.

Scope of Review

This review will summarize and scrutinize known approaches for making glucose-sensitive insulin therapies. Notably, systems described in patent applications will be extensively covered, which has been not the case for earlier reviews of the area.

Major Conclusions

The vast majority of published systems are not suitable for product development, but a few glucose-sensitive insulin concepts have recently reached clinical trials, and there is hope that glucose-sensitive insulin will become available to people with diabetes within the coming years.

中文翻译：

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评论：葡萄糖敏感胰岛素

背景

低血糖是一种可怕的低血糖状况，在使用胰岛素治疗的糖尿病患者中很常见。自 1970 年代以来，人们一直在追求通过设计一种胰岛素制剂来预防低血糖症的想法，该制剂可以自动调整其生物活性以适应血糖水平的波动，但尽管发表了数千篇文章，但没有一个系统可以很好地用于实际应用.

审查范围

这篇综述将总结和审查已知的葡萄糖敏感性胰岛素治疗方法。值得注意的是，专利申请中描述的系统将被广泛涵盖，而早先对该领域的审查并非如此。

主要结论

绝大多数已发表的系统都不适合产品开发，但一些葡萄糖敏感胰岛素概念最近已进入临床试验，并且有希望在未来几年内为糖尿病患者提供葡萄糖敏感胰岛素。