The relationship between optical coherence tomography (OCT) measurements of the retinal structures has been described for various neurological diseases including Multiple Sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Brain volume changes, both globally and by area, are associated with some of these same diseases, yet the correlation of OCT and disease is not fully elucidated. Our study looked at normal subjects, at the correlation of OCT measurements and brain volumes, both globally and for specific regions including the pericalcarine grey matter, entorhinal grey matter, and cerebellar volume using a retrospective, cross-sectional cohort study design. Thickness of the retinal nerve fiber layer (RNFL) as measured by OCT, correlated with volume of the pericalcarine grey matter, when adjusted for age and gender. Similarly, thickness of the ganglion cell layer-inner plexiform layer complex may be associated with both entorhinal grey matter volumes and total cerebellar volumes, although our pilot study did not reach statistical significance. This suggests that both eye and brain volumes follow a similar trajectory and understanding the inter-relationship of these structures will aid in the analysis of changes seen in disease. Further studies are needed to longitudinally demonstrate these relationships.

中文翻译：

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视神经乳头和视网膜的 OCT 参数作为正常人群脑容量的替代标志物，一项初步研究

对于包括多发性硬化症 (MS)、阿尔茨海默病 (AD) 和帕金森病 (PD) 在内的各种神经系统疾病，已经描述了视网膜结构的光学相干断层扫描 (OCT) 测量之间的关系。脑容量的变化，无论是全球的还是区域的，都与这些相同的疾病中的一些有关，但 OCT 与疾病的相关性尚未完全阐明。我们的研究使用回顾性、横断面队列研究设计，研究了正常受试者的 OCT 测量值与脑容量的相关性，包括全球范围内和特定区域，包括皮层周围灰质、内嗅灰质和小脑体积。当根据年龄和性别进行调整时，通过 OCT 测量的视网膜神经纤维层 (RNFL) 的厚度与骨膜周围灰质的体积相关。同样，神经节细胞层-内丛状层复合体的厚度可能与内嗅灰质体积和小脑总体积有关，尽管我们的初步研究没有达到统计学意义。这表明眼睛和大脑体积都遵循相似的轨迹，了解这些结构的相互关系将有助于分析疾病中的变化。需要进一步的研究来纵向证明这些关系。这表明眼睛和大脑体积都遵循相似的轨迹，了解这些结构的相互关系将有助于分析疾病中的变化。需要进一步的研究来纵向证明这些关系。这表明眼睛和大脑体积都遵循相似的轨迹，了解这些结构的相互关系将有助于分析疾病中的变化。需要进一步的研究来纵向证明这些关系。