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Thin film composite structured Janus membrane for fast gravity-driven separation of a trace of blood
Journal of Membrane Science ( IF 9.5 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.memsci.2020.118853
Xingzhen Zhang , Yuzhang Zhu , Wangxi Fang , Liangliang Gui , Jingya Zhang , Aqiang Wang , Jian Jin

Abstract Accurately monitoring blood glucose in real-time is highly required for diabetes. Utilizing membrane to realize fast separation of a trace of blood is significant for accurately testing blood glucose. In this work, we designed a Janus membrane with thin film composite structure by electrospinning polyurethane (PU) on Ca3(PO4)2-coated nylon mesh. This Janus membrane exhibited directional liquid transport performance and liquid wastage reduction during separation through optimizing the surface wettability, pore parameters and asymmetric structures of membrane. When a trace of water with volume as small as 3 μL was dipped on the hydrophobic side with pore size of around 1.1 μm, this water droplet could easily penetrate through the Janus membrane within 2.9 s under only gravity and liquid wastage reduction was achieved at the same time (D2/D1 = 1.27), suggesting an excellent liquid transportation performance. The blood glucose meter integrated with this Janus membrane could efficiently remove red blood cells from 10 μL blood within 7.2 s. As a result, the sensitivity of the blood glucose meter increased by 4.5%.

中文翻译:

用于快速重力驱动分离微量血液的薄膜复合结构 Janus 膜

摘要 糖尿病患者迫切需要实时准确监测血糖。利用膜实现微量血液的快速分离对于准确检测血糖具有重要意义。在这项工作中,我们通过在 Ca3(PO4)2 涂层尼龙网上静电纺丝聚氨酯 (PU) 设计了一种具有薄膜复合结构的 Janus 膜。该 Janus 膜通过优化膜的表面润湿性、孔隙参数和不对称结构,在分离过程中表现出定向液体传输性能和减少液体浪费。当微量体积小至 3 μL 的水浸入孔径约为 1.1 μm 的疏水侧时,该水滴可以在 2 内轻松穿透 Janus 膜。仅重力作用下 9 秒,同时减少液体浪费(D2 / D1 = 1.27),表明具有出色的液体输送性能。与这种 Janus 膜集成的血糖仪可以在 7.2 秒内有效地从 10 μL 血液中去除红细胞。结果,血糖仪的灵敏度提高了4.5%。
更新日期:2021-02-01
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