The present study investigates the adsorptive interaction of rice husk ash (RHA) with Ofloxacin (OFL) antibiotic. The OFL loaded RHA was studied for its disposability by solidification to find its possible use as a building material. Further, toxicity analysis of leachate from the solidified RHA was also studied for probable leaching of OFL. The effects of adsorption parameters such as initial pH, the dosage of RHA (m), initial OFL concentration (C₀), and contact time (t) on the responses % OFL removal (X₁) and adsorption capacity (mg/g) (X₂) were evaluated using the central composite design (CCD) based on response surface method (RSM). Kinetic and thermodynamic studies were performed at optimized parameters, and adsorption equilibrium data were illustrated by using Langmuir, Redlich-Peterson (R-P), and Tempkin isotherm models. Optimum condition was found as m = 7.94 g/L, t = 430 min and pH = 6, and at this actual responses X₁ and X₂ were evaluated as 79.71% and 6.28 mg/g, respectively. Pseudo-first-order kinetic fitted best for the adsorption kinetic data. Toxicity analysis of leachate from solidified RHA indicated that most of the OFL was encapsulated inside the cement and the OFL present in leachate is not sufficient to eradicate the growth of E.coli and Bacillus subtilis.

本研究调查稻壳灰（RHA）与氧氟沙星（OFL）抗生素的吸附相互作用。通过固化研究了装有OFL的RHA的可处理性，发现其可能用作建筑材料。此外，还研究了从固化的RHA中浸出液的毒性分析，以用于OFL的可能浸出。初始pH值，RHA的用量（m），初始OFL浓度（C ₀）和接触时间（t）等吸附参数对OFL去除率（X ₁）和吸附容量（mg / g）的响应的影响（X ₂）是使用基于响应面法（RSM）的中央复合设计（CCD）进行评估的。在优化参数下进行了动力学和热力学研究，并通过使用Langmuir，Redlich-Peterson（RP）和Tempkin等温线模型说明了吸附平衡数据。发现最佳条件为m  = 7.94 g / L ，t  = 430 min，pH  = 6，在此实际响应下X ₁和X ₂分别评估为79.71％和6.28 mg / g。伪一阶动力学最适合吸附动力学数据。固化RHA中渗滤液的毒性分析表明，大部分OFL都包裹在水泥中，渗滤液中存在的OFL不足以消除大肠杆菌和枯草芽孢杆菌的生长。