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Dual Prophylactic/Therapeutic Potential of Date Seed, and Nigella and Olive Oils-based Nutraceutical Formulation in Rats with Experimentally-Induced Alzheimer's Disease: A Mechanistic Insight
Journal of Chemical Neuroanatomy ( IF 2.8 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.jchemneu.2020.101878
Samar R. Saleh , Sherien A. Abdelhady , Amira R. Khattab , Wessam F. El-Hadidy

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a multifactorial etiology and significantly increasing incidence during the last decade. Hence, developing an effective therapy is crucial for public health. The current study aimed to examine the dual prophylactic/therapeutic potential of a nutraceutical formula based on aqueous extract of roasted date seeds, and nigella and virgin-olive oils against experimentally-induced Alzheimer's disease in rats. Alzheimer's disease-like pathology was induced in male Wistar rats using oral CuSO4 (200 mg/Kg/day for two months). The nutraceutical formula was given orally to experimental animals (10 mL/kg/d) for 14 days before (as prophylaxis) and after Alzheimer induction and its therapeutic effect in both cases is tested in comparison to donepezil (0.5 mg/kg/d). The nutraceutical formula was found to ameliorate the CuSO4-induced neuronal damage and regenerate the affected hippocampus tissue and significantly improvemedin learning ability. The formula was also effective in decreasing brain amyloid-β, tau protein, TNF-α level, iNOS level in hippocampus, oxidative stress level, and inhibiting acetylcholinesterase activity and expression in brain and hippocampus, respectively. Further, an increase in GSH levels, and activities of SOD and GST and levels of hippocampus ADAM 17 and brain phospholipids was observed. In conclusion, the studied nutraceutical formula is proved to be effective in ameliorating Alzheimer's neurodegenerative progression with added-prophylactic potential.

中文翻译:

枣子和基于黑种草和橄榄油的营养制剂在实验诱导的阿尔茨海默病大鼠中的双重预防/治疗潜力:机制洞察

阿尔茨海默病 (AD) 是一种进行性神经退行性疾病,具有多因素病因,在过去十年中发病率显着增加。因此,开发有效的疗法对公共卫生至关重要。目前的研究旨在检查基于烤枣种子、黑种草和初榨橄榄油的水提取物的营养配方对实验诱导的大鼠阿尔茨海默病的双重预防/治疗潜力。使用口服 CuSO4(200 毫克/公斤/天,两个月)在雄性 Wistar 大鼠中诱导阿尔茨海默病样病理。在阿尔茨海默症诱导之前(作为预防)和之后 14 天,将营养配方口服给实验动物 (10 mL/kg/d),并与多奈哌齐 (0.5 mg/kg/d) 进行比较,测试其在两种情况下的治疗效果. 发现该营养配方可改善 CuSO4 引起的神经元损伤,并使受影响的海马组织再生,并显着提高医学学习能力。该方还有效降低脑淀粉样蛋白-β、tau 蛋白、TNF-α 水平、海马 iNOS 水平、氧化应激水平,并分别抑制大脑和海马中乙酰胆碱酯酶的活性和表达。此外,还观察到 GSH 水平、SOD 和 GST 活性以及海马 ADAM 17 和脑磷脂水平的增加。总之,所研究的营养配方被证明可有效改善阿尔茨海默氏症的神经退行性进展,并具有额外的预防潜力。
更新日期:2020-12-01
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