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Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic disorders
European Journal of Cell Biology ( IF 6.6 ) Pub Date : 2020-11-02 , DOI: 10.1016/j.ejcb.2020.151128
P Vineeth Daniel 1 , Prosenjit Mondal 1
Affiliation  

ChREBP is the master regulator of carbohydrate dependent glycolytic and lipogenic flux within metabolic tissues. It plays a vital role in hyper-calorific milieu by activating glycolysis, lipogenesis along with pentose phosphate shunt and glycogen synthesis, fostering immediate reduction in the systemic glycemic levels. Liver being the primary organ to sense disproportionate dietary intake and linked physiological stress, stimulates ChREBP to perform the aforementioned processes. Activated ChREBP also inhibits lipolysis and encourages proper disposal of excessive triglycerides into adipocytes from the liver ablating hepatic intracellular lipid trafficking. Chronic overeating or onset of positive energy balance, hyper-activates ChREBP and signals development, intensification of hepato-metabolic disorders, and allied discrepancies in the whole-body metabolic functioning. ChREBP thus gets negatively connotated as the primary regulator of hepatic disorders, owing to its inherent features as the primary glycemic sensor and the only transcription factor that can transduce glucose-dependent glycolytic and lipogenic signals. Through this review, we - try to recapitulate and emphasize on the sanative events coordinated by ChREBP in several pathophysiological states. In totality, we aim to uncouple the disease-causing aspects of ChREBP from its positive attributes evoked during a metabolic crisis, in hepato-metabolic diseases.



中文翻译:

ChREBP 在肝代谢疾病中的病因和健康动态

ChREBP 是代谢组织内碳水化合物依赖性糖酵解和脂肪生成通量的主要调节器。它通过激活糖酵解、脂肪生成以及磷酸戊糖分流和糖原合成,在高热量环境中发挥重要作用,促进全身血糖水平的立即降低。肝脏是感知不成比例的饮食摄入和相关生理压力的主要器官,刺激 ChREBP 执行上述过程。活化的 ChREBP 还抑制脂肪分解,并鼓励将过量的甘油三酯从肝脏中适当处理到脂肪细胞中,从而消除肝脏细胞内脂质运输。慢性暴饮暴食或开始正能量平衡,过度激活 ChREBP 和信号发展,肝代谢紊乱加剧,以及全身代谢功能的相关差异。由于 ChREBP 作为主要血糖传感器的固有特征和唯一可以转导依赖葡萄糖的糖酵解和脂肪生成信号的转录因子,因此被负面地认为是肝脏疾病的主要调节剂。通过这篇综述,我们试图概括和强调 ChREBP 在几种病理生理状态下协调的健康事件。总的来说,我们的目标是将 ChREBP 的致病方面与其在代谢危机期间引起的积极属性分离,在肝代谢疾病中。由于其作为主要血糖传感器的固有特征和唯一可以转导葡萄糖依赖性糖酵解和脂肪生成信号的转录因子。通过这篇综述,我们试图概括和强调 ChREBP 在几种病理生理状态下协调的健康事件。总的来说,我们的目标是将 ChREBP 的致病方面与其在代谢危机期间引起的积极属性分离,在肝代谢疾病中。由于其作为主要血糖传感器的固有特征和唯一可以转导葡萄糖依赖性糖酵解和脂肪生成信号的转录因子。通过这篇综述,我们试图概括和强调 ChREBP 在几种病理生理状态下协调的健康事件。总的来说,我们的目标是将 ChREBP 的致病方面与其在代谢危机期间引起的积极属性分离,在肝代谢疾病中。

更新日期:2020-11-22
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