Fundamental responses to any stimulus are mediated through the expression of exclusive and specific protein arrays, inside or outside the cellular milieu. Understanding these specific arrays of proteins could lead to a way to ameliorate the situations raised by such insults. For the past few decades and with the advancement of molecular tools, the radiation-affected proteome has been a focus of research. These protein biomarkers have provided insights to develop biodosimetry and diagnostic approaches, and to determine the response of tumors versus normal cells to different radiations to improve radiation therapy (RT). In this review, we elaborate on radiation proteomic studies and their possible role in the development of modalities for radiation countermeasures, radiation biodosimetry, and carcinogenesis applications.

对任何刺激的基本反应都是通过细胞环境内部或外部的专有和特定蛋白质阵列的表达来介导的。了解这些特定的蛋白质阵列可能会导致一种改善这种侮辱所引起的情况的方法。在过去的几十年里，随着分子工具的进步，受辐射影响的蛋白质组一直是研究的重点。这些蛋白质生物标志物为开发生物剂量学和诊断方法以及确定肿瘤与正常细胞对不同辐射的反应以改善放射治疗 (RT) 提供了见解。在这篇综述中，我们详细阐述了辐射蛋白质组学研究及其在辐射对策、辐射生物剂量学和致癌应用模式的发展中可能发挥的作用。