Gold nanoparticles (AuNPs) have garnered much attention as contrast agents for computerized tomography (CT) because of their facile synthesis and surface functionalization, in addition to their significant X-ray attenuation and minimal cytotoxicity. Cell labeling using AuNPs and tracking of the labeled cells using CT has become a time-efficient and cost-effective method. Actively targeted AuNPs can enhance CT contrast and sensitivity, and further reduce the radiation dosage needed during CT imaging. In this review, we summarize the state-of-the-art use of AuNPs in CT for cell tracking, including the precautionary steps necessary for their use and the difficulty in translating the process into clinical use.

除了显着的 X 射线衰减和最小的细胞毒性外，金纳米粒子 (AuNPs) 作为计算机断层扫描 (CT) 的造影剂已引起广泛关注，因为它们易于合成和表面功能化。使用 AuNPs 进行细胞标记并使用 CT 跟踪标记的细胞已成为一种省时且具有成本效益的方法。主动靶向 AuNPs 可以增强 CT 对比度和灵敏度，并进一步降低 CT 成像所需的辐射剂量。在这篇综述中，我们总结了金纳米粒子在 CT 中用于细胞追踪的最先进的使用，包括使用它们所需的预防步骤以及将过程转化为临床使用的困难。