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The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system
Cytokine & Growth Factor Reviews ( IF 13.0 ) Pub Date : 2020-11-02 , DOI: 10.1016/j.cytogfr.2020.10.008
Sean Paz 1 , Anastasia Ritchie 1 , Christopher Mauer 1 , Massimo Caputi 1
Affiliation  

Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The aim of this review is to highlight recent findings in the functions of this protein and to describe its role in immune system development, functions and regulation.



中文翻译:

RNA结合蛋白SRSF1是免疫系统中基因表达和调控的总开关

丝氨酸/精氨酸剪接因子 1 (SRSF1) 是一种在大多数组织中大量表达的 RNA 结合蛋白。SRSF1 的多效性功能通过调节转录、加工、通过核孔输出和新生 RNA 转录物的翻译中的主要步骤在基因表达中发挥多种作用。这篇综述的目的是强调这种蛋白质功能的最新发现,并描述它在免疫系统发育、功能和调节中的作用。

更新日期:2020-11-02
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