Metabolic reprogramming confers cancer cells plasticity and viability under harsh conditions. Such active alterations lead to cell metabolic dependency, which can be exploited as an attractive target in development of effective antitumor therapies. Similar to cancer cells, activated T cells also execute global metabolic reprogramming for their proliferation and effector functions when recruited to the tumor microenvironment (TME). However, the high metabolic activity of rapidly proliferating cancer cells can compete for nutrients with immune cells in the TME, and consequently, suppressing their anti-tumor functions. Thus, therapeutic strategies could aim to restore T cell metabolism and anti-tumor responses in the TME by targeting the metabolic dependence of cancer cells. In this review, we highlight current research progress on metabolic reprogramming and the interplay between cancer cells and immune cells. We also discuss potential therapeutic intervention strategies for targeting metabolic pathways to improve cancer immunotherapy efficacy.

代谢重编程赋予癌细胞在恶劣条件下的可塑性和活力。这种主动改变导致细胞代谢依赖性，这可以作为开发有效抗肿瘤疗法的有吸引力的目标。与癌细胞类似，活化的 T 细胞在被招募到肿瘤微环境 (TME) 时，也会对其增殖和效应功能进行全局代谢重编程。然而，快速增殖的癌细胞的高代谢活动可以与 TME 中的免疫细胞竞争营养，从而抑制其抗肿瘤功能。因此，治疗策略可能旨在通过靶向癌细胞的代谢依赖性来恢复 TME 中的 T 细胞代谢和抗肿瘤反应。在本次审查中，