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TL1A/TNFR2 Axis Enhances Immunoregulatory Effects of Bone Marrow Derived Mesenchymal Stem Cell by Indian Hedgehog Signaling Pathway.
International Journal of Stem Cells ( IF 2.3 ) Pub Date : 2020-10-31 , DOI: 10.15283/ijsc19121 Mahmoud Al-Azab 1, 2 , Williams Walana 1, 3 , Jing Wei 1 , Weiping Li 1 , Yawei Tang 1 , Xiaoqing Wei 4 , Marwan Almoiliqy 5 , Abdullah Shopit 5 , Elrayah Eltahir Abbas 6 , Salah Adlat 7 , Mohammed Awsh 5 , Xia Li 1 , Bing Wang 1
International Journal of Stem Cells ( IF 2.3 ) Pub Date : 2020-10-31 , DOI: 10.15283/ijsc19121 Mahmoud Al-Azab 1, 2 , Williams Walana 1, 3 , Jing Wei 1 , Weiping Li 1 , Yawei Tang 1 , Xiaoqing Wei 4 , Marwan Almoiliqy 5 , Abdullah Shopit 5 , Elrayah Eltahir Abbas 6 , Salah Adlat 7 , Mohammed Awsh 5 , Xia Li 1 , Bing Wang 1
Affiliation
The immunomodulatory potential of mesenchymal stem cells (MSCs) can be regulated by a variety of molecules, especially cytokines. The inflammatory cytokine, TNF-like ligand 1A (TL1A), has been reported as an inflammation stimulator in multiple autoimmune diseases. Here, we studied the effects of TL1A/TNF-receptor 2 (TNFR2) pathway on the therapeutic potency of bone marrow-derived MSCs (BMSCs).
中文翻译：
TL1A/TNFR2 轴通过印度刺猬信号通路增强骨髓来源间充质干细胞的免疫调节作用。
间充质干细胞 (MSCs) 的免疫调节潜力可以由多种分子调节，尤其是细胞因子。据报道，炎症细胞因子 TNF 样配体 1A (TL1A) 是多种自身免疫性疾病的炎症刺激剂。在这里，我们研究了 TL1A/TNF 受体 2 (TNFR2) 通路对骨髓来源的 MSCs (BMSCs) 治疗效力的影响。
更新日期：2020-11-03
中文翻译：
TL1A/TNFR2 轴通过印度刺猬信号通路增强骨髓来源间充质干细胞的免疫调节作用。
间充质干细胞 (MSCs) 的免疫调节潜力可以由多种分子调节，尤其是细胞因子。据报道，炎症细胞因子 TNF 样配体 1A (TL1A) 是多种自身免疫性疾病的炎症刺激剂。在这里，我们研究了 TL1A/TNF 受体 2 (TNFR2) 通路对骨髓来源的 MSCs (BMSCs) 治疗效力的影响。
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