Imaging with terahertz (THz) waves has been expected as a non-invasive/non-staining visualization tool for breast cancer margins during surgeries. Breast cancer is a generic name for a heterogeneous lesion comprising invasive adenocarcinoma, in situ adenocarcinoma, most frequently in the form of ductal carcinoma in situ (DCIS) and benign tissues. Until now, THz imaging has focused on invasive adenocarcinoma; however, THz analysis of DCIS has hardly been performed. One of the reasons is that the size of an individual DCIS lesion, ranging from 50 to 500 µ m, is typically much smaller than that of an invasive carcinoma. This makes it difficult to identify these lesions by THz imaging, which has only a diffraction-limited spatial resolution of several millimeters. To overcome this drawback, we have developed a scanning point terahertz source (SPoTS) microscope with a resolution of 20 µ m, in which a near-infrared-pump-laser-induced two-dimensionally-scannab...

中文翻译：

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乳腺导管原位癌（DCIS）的太赫兹近场显微镜

太赫兹（THz）波成像已被期望作为外科手术期间乳腺癌切缘的一种非侵入性/非染色性可视化工具。乳腺癌是包括浸润性腺癌，原位腺癌（通常以导管原位癌（DCIS）和良性组织形式）的异质性病变的总称。迄今为止，太赫兹成像技术一直专注于浸润性腺癌。但是，几乎没有对DCIS进行太赫兹分析。原因之一是单个DCIS病变的大小通常在50至500 µm之间，比浸润性癌小得多。这使得难以通过太赫兹成像来识别这些病变，太赫兹成像仅具有几毫米的衍射极限空间分辨率。为了克服这个缺点，