Methoxy poly(ethylene glycol) amine with a molecular weight of 5 K and -caprolactone with a molecular weight of 3 K were conjugated to five lysine residues with molecular weight and M w / M n of 9.6 K and 1.04, respectively. The shift of peak molecular weight and narrow molecular weight distribution in a gel permeation chromatography (GPC) trace without any noticeable shoulder as well as 1 H nuclear magnetic resonance analysis confirmed the successful synthesis of the copolymer. Polymeric micelles, of size around 60 nm, were formed by dialysis and crosslinked micelles (CMs) were prepared by adding a crosslinker, terephthalaldehyde, to generate weak acid-labile benzoic-imine bonds in the interface of the micelle-forming amphiphilic copolymer. The critical micelle concentrations of non-crosslinked micelles and CMs were determined to be 4.26 × 10 –2 mg ml −1 and 7.01 × 10 –3 mg ml −1 , respectively....

中文翻译：

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功能化的PEG-寡聚（L-赖氨酸）-PCL胶束系统，用于基于pH敏感的降解来递送生物活性剂

分子量为5 K的甲氧基聚（乙二醇）胺 分子量为3 K的己内酯与5个赖氨酸残基共轭，分子量分别为9.6 K和M w / M n为1.04。在没有任何明显肩峰的凝胶渗透色谱法（GPC）中，峰分子量的变化和窄分子量分布的变化以及1 H核磁共振分析证实了该共聚物的成功合成。通过透析形成大小约为60 nm的聚合物胶束，并通过添加交联剂对苯二甲醛制备交联胶束（CMs），以在形成胶束的两亲共聚物的界面中产生弱酸不稳定的苯甲酸-亚胺键。未交联的胶束和CM的临界胶束浓度确定为4.26 × 10 –2 mg ml -1和7.01 × 分别为10 –3 mg ml -1 ....