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Computational feasibility of simulating changes in blood flow through whole-organ vascular networks from radiation injury
Biomedical Physics & Engineering Express Pub Date : 2020-10-21 , DOI: 10.1088/2057-1976/abaf5c
William P Donahue 1 , Wayne D Newhauser 1, 2 , Xin Li 3 , Feng Chen 4 , Joyoni Dey 1
Affiliation  

Vasculature is necessary to the healthy function of most tissues. In radiation therapy, injury of the vasculature can have both beneficial and detrimental effects, such as tumor starvation, cardiac fibrosis, and white-matter necrosis. These effects are caused by changes in blood flow due to the vascular injury. Previously, research has focused on simulating the radiation injury of vasculature in small volumes of tissue, ignoring the systemic effects of local damage on blood flow. Little is known about the computational feasibility of simulating the radiation injury to whole-organ vascular networks. The goal of this study was to test the computational feasibility of simulating the dose deposition to a whole-organ vascular network and the resulting change in blood flow. To do this, we developed an amorphous track-structure model to transport radiation and combined this with existing methods to model the vasculature and blood flow rates. We assessed the algorithm's computational scalability, execution time, and memory usage. The data demonstrated it is computationally feasible to calculate the radiation dose and resulting changes in blood flow from 2 million protons to a network comprising 8.5 billion blood vessels (approximately the number in the human brain) in 87 hours using a 128-node cluster. Furthermore, the algorithm demonstrated both strong and weak scalability, meaning that additional computational resources can reduce the execution time further. These results demonstrate, for the first time, that it is computationally feasible to calculate radiation dose deposition in whole-organ vascular networks. These findings provide key insights into the computational aspects of modeling whole-organ radiation damage. Modeling the effects radiation has on vasculature could prove useful in the study of radiation effects on tissues, organs, and organisms.

中文翻译:

模拟辐射损伤通过全器官血管网络的血流变化的计算可行性

脉管系统是大多数组织的健康功能所必需的。在放射治疗中,脉管系统的损伤可能会产生有益和有害的影响,例如肿瘤饥饿、心脏纤维化和白质坏死。这些影响是由血管损伤引起的血流变化引起的。以前,研究集中在模拟小体积组织中脉管系统的辐射损伤,而忽略了局部损伤对血流的全身影响。对模拟全器官血管网络的辐射损伤的计算可行性知之甚少。本研究的目的是测试模拟整个器官血管网络的剂量沉积以及由此产生的血流变化的计算可行性。去做这个,我们开发了一种无定形轨道结构模型来传输辐射,并将其与现有方法相结合来模拟脉管系统和血流速率。我们评估了算法的计算可扩展性、执行时间和内存使用情况。数据表明,使用 128 节点集群在 87 小时内计算辐射剂量和由此产生的血流变化从 200 万个质子到包含 85 亿条血管(大约人脑中的数量)的网络在计算上是可行的。此外,该算法展示了强和弱的可扩展性,这意味着额外的计算资源可以进一步减少执行时间。这些结果首次证明,计算全器官血管网络中的辐射剂量沉积在计算上是可行的。这些发现为模拟全器官辐射损伤的计算方面提供了关键见解。模拟辐射对脉管系统的影响可能有助于研究辐射对组织、器官和生物体的影响。
更新日期:2020-10-21
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