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Spatially confined responses of mouse visual cortex to intracortical magnetic stimulation from micro-coils
Journal of Neural Engineering ( IF 4 ) Pub Date : 2020-10-22 , DOI: 10.1088/1741-2552/abbd22
Sang Baek Ryu 1 , Angelique C Paulk 2 , Jimmy C Yang 1, 2 , Mehran Ganji 3 , Shadi A Dayeh 3 , Sydney S Cash 2 , Shelley I Fried 1, 4 , Seung Woo Lee 1
Affiliation  

Objective. Electrical stimulation via microelectrodes implanted in cortex has been suggested as a potential treatment for a wide range of neurological disorders. Despite some success however, the effectiveness of conventional electrodes remains limited, in part due to an inability to create specific patterns of neural activity around each electrode and in part due to challenges with maintaining a stable interface. The use of implantable micro-coils to magnetically stimulate the cortex has the potential to overcome these limitations because the asymmetric fields from coils can be harnessed to selectively activate some neurons, e.g. vertically-oriented pyramidal neurons while avoiding others, e.g. horizontally-oriented passing axons. In vitro experiments have shown that activation is indeed confined with micro-coils but their effectiveness in the intact brain of living animals has not been evaluated. Approach. To assess the efficacy of stimulation, a 128-chan...

中文翻译:

小鼠视觉皮层对来自微线圈的皮层内磁刺激的空间限制反应

客观的。通过植入皮层的微电极进行电刺激已被认为是治疗多种神经系统疾病的潜在疗法。然而,尽管取得了一些成功,但传统电极的有效性仍然有限,部分原因是无法在每个电极周围创建特定的神经活动模式,部分原因是维持稳定界面的挑战。使用植入式微线圈对皮质进行磁刺激有可能克服这些限制,因为可以利用来自线圈的不对称场来选择性地激活一些神经元,例如垂直定向的锥体神经元,同时避免其他神经元,例如水平定向的传递轴突. 体外实验表明,激活确实受限于微线圈,但尚未评估它们在活体动物完整大脑中的有效性。方法。为了评估刺激的功效,一个 128 通道...
更新日期:2020-10-30
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