We present our findings in an atypical case of ocular syphilis with optic disc neovascularization that was treated with intravitreal bevacizumab and followed by multimodal imaging and electroretinography. A 29-year-old man presented with a chief complaint of night blindness of one-year duration. Our initial examination showed that an optic disc neovascularization was present, and the optical coherence tomographic (OCT) images showed a reduction in the length of the ellipsoid zone of both eyes. Fluorescein angiography showed leakage from the optic disc neovascular tissue, and the presence of nonperfused areas in the peripheral retina. Blood test was strongly positive for syphilis. He was administered oral amoxicillin and prednisolone. He was also treated with an intravitreal injection of bevacizumab which led to a rapid suppression of the neovascularization. However, panretinal photocoagulation had to be performed because OCT angiography and fluorescein angiography detected residual neovascularization. Although these treatments suppressed the activity of the ocular syphilis, electrophysiological improvements were not seen even 1 year after the initial treatment. OCT angiography and electroretinogram are useful techniques for monitoring the effectiveness of the treatments.

中文翻译：

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贝伐单抗治疗OCT血管造影和视网膜电图评价眼梅毒合并视神经乳头新血管形成

我们在玻璃体腔贝伐单抗治疗后发生的非典型眼梅毒伴视盘新血管形成病例中介绍我们的发现，然后进行多模式成像和视网膜电图检查。一名29岁的男子主诉夜盲症为一年。我们的初步检查显示存在视盘新血管形成，并且光学相干断层扫描（OCT）图像显示两只眼睛的椭球区长度减少。荧光素血管造影显示视神经乳头新血管组织漏出，并且周围视网膜中存在非灌注区域。验血对梅毒强阳性。他被口服阿莫西林和泼尼松龙。还通过玻璃体内注射贝伐单抗治疗了他，从而迅速抑制了新血管形成。然而，由于OCT血管造影和荧光素血管造影检测到残留的新血管形成，因此必须进行全视网膜光凝。尽管这些治疗抑制了眼梅毒的活性，但即使在初始治疗后的一年，也未见电生理改善。OCT血管造影和视网膜电图是用于监测治疗效果的有用技术。初始治疗后一年甚至都未见电生理改善。OCT血管造影和视网膜电图是用于监测治疗效果的有用技术。初次治疗后一年仍未见电生理改善。OCT血管造影和视网膜电图是用于监测治疗效果的有用技术。