Orthostatic hypotension (OH) is a common non-motor symptom in Parkinson’s disease (PD) and is linked with increased mortality risk among the elderly. Although the locus coeruleus (LC) is the major source of noradrenaline (NA) modulation in the brain, its role in the pathogenesis of OH in PD remainslargely elusive. Here we examined 44 well characterized postmortem brains of PD patients and available clinical data to explore the relationship between OH and LC pathology in PD. Our results failed to indicate that the LC pathology as well as the substantia nigra pathology were robustly associated with the presence of OH in PD patients, suggesting targeting LC norepinephrinergic system alone may not be sufficient to treat OH in PD.

中文翻译：

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蓝斑病病理学与帕金森病体位性低血压缺乏关联

直立性低血压 (OH) 是帕金森病 (PD) 中常见的非运动症状，与老年人死亡风险增加有关。虽然蓝斑 (LC) 是大脑中去甲肾上腺素 (NA) 调节的主要来源，但其在 PD 中 OH 发病机制中的作用仍然难以捉摸。在这里，我们检查了 44 个特征明确的 PD 患者的死后大脑和可用的临床数据，以探索 PD 中 OH 和 LC 病理之间的关系。我们的结果未能表明 LC 病理学以及黑质病理学与 PD 患者中 OH 的存在密切相关，这表明仅针对 LC 去甲肾上腺素能系统可能不足以治疗 PD 中的 OH。